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KMID : 0985420180400010046
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Laboratory Medicine and Quality Assurance
2018 Volume.40 No. 1 p.46 ~ p.49
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Usefulness of P50,std for the Diagnostic Work-up of Patients with Erythrocytosis
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Shin Sang-Yong
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Abstract
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High oxygen-affinity hemoglobin (Hb) variants and a 2,3-diphosphoglycerate (2,3-DPG) deficiency could cause congenital (familial) erythrocytosis. High oxygen-affinity Hb variants and a 2,3-DPG deficiency might result in low tissue oxygen tension left-shifted oxygen dissociation curves and reduction in the standard P50 value (P50,std, oxygen tension at which haemoglobin is 50% saturated). Hence, the P50,std value is considered while formulating diagnostic strategies for erythrocytosis. In this study, we established a reference range for P50,std using an International Federation of Clinical Chemistry and Laboratory Medicine-approved equation (Hill’s equation) for individual single venous/arterial blood samples. Blood gas analysis results of 243 samples with oxygen saturation ranging from 40%?90% (Hb＜16 mg/dL) were selected. The reference range of P50,std was in the 2.5th?97.5th percentile, and was 25.9?27.3 mm Hg. Hill’s equation is a simple approved method for evaluating the P50,std values. Only a single sample of venous or arterial blood and a blood gas analyser are required to obtain the P50,std. Our study provides a useful tool for the diagnostic work-up of patients with erythrocytosis.
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KEYWORD
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Hill’s equation, P50, Polycythemia
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